Clifton E Barry Selected Research

pretomanid

1/2014	Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis.
1/2012	Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles.
5/2009	The mechanism of action of PA-824: Novel insights from transcriptional profiling.
11/2008	PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.
4/2008	Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824.
10/2006	Mycobacterium leprae is naturally resistant to PA-824.
1/2006	Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis.

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Clifton E Barry Research Topics

Disease

105	Tuberculosis (Tuberculoses) 11/2021 - 07/2002
33	Infections 01/2022 - 04/2003
11	Granuloma 10/2021 - 12/2003
11	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 01/2021 - 01/2010
8	Extensively Drug-Resistant Tuberculosis 01/2017 - 01/2008
7	Pulmonary Tuberculosis 10/2021 - 12/2003
6	Persistent Infection 01/2021 - 08/2003
5	Inflammation (Inflammations) 01/2021 - 10/2016
4	Communicable Diseases (Infectious Diseases) 11/2022 - 11/2011
3	Hypoxia (Hypoxemia) 04/2016 - 10/2011
3	Latent Tuberculosis 05/2015 - 07/2008
3	Starvation 03/2014 - 07/2008
2	Lung Diseases (Lung Disease) 01/2022 - 07/2015
2	Extrapulmonary Tuberculosis 10/2021 - 11/2019
2	Neoplasms (Cancer) 01/2021 - 02/2015
2	Disease Progression 10/2019 - 07/2014
2	Necrosis 04/2016 - 09/2004
2	Latent Infection 08/2012 - 06/2008
1	Pleural Tuberculosis 10/2021
1	HIV Infections (HIV Infection) 10/2021
1	Ototoxicity 01/2021
1	Atherosclerosis 01/2018

Drug/Important Bio-Agent (IBA)

46	Pharmaceutical PreparationsIBA 11/2022 - 01/2008
13	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 01/2004
10	EnzymesIBA 10/2019 - 07/2008
9	Rifampin (Rifampicin)FDA LinkGeneric 10/2021 - 05/2010
9	Proteins (Proteins, Gene)FDA Link 01/2021 - 07/2002
9	LipidsIBA 11/2019 - 09/2004
8	Isoniazid (Ftivazide)FDA LinkGeneric 01/2017 - 05/2009
7	pretomanidIBA 01/2014 - 01/2006
6	Biomarkers (Surrogate Marker)IBA 11/2019 - 01/2012
6	FluoroquinolonesIBA 01/2017 - 10/2004
6	Oxygen (Dioxygen)IBA 04/2016 - 07/2002
5	Kanamycin FDA Link 01/2021 - 01/2008
5	Streptomycin (Streptomycin Sulfate)FDA Link 01/2021 - 01/2008
5	Pyrazinamide FDA LinkGeneric 01/2018 - 09/2011
5	DNA (Deoxyribonucleic Acid)IBA 01/2017 - 04/2003
5	VaccinesIBA 10/2016 - 05/2010
5	Linezolid (Zyvox)FDA Link 11/2015 - 06/2012
5	CytokinesIBA 07/2014 - 05/2004
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2010 - 12/2003
4	Amikacin (A.M.K)FDA LinkGeneric 01/2021 - 02/2010
4	Moxifloxacin (Avelox)FDA Link 01/2017 - 10/2004
4	IronIBA 05/2015 - 02/2005
4	NitroimidazolesIBA 11/2012 - 01/2004
3	AminoglycosidesIBA 01/2021 - 02/2010
3	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 02/2020 - 07/2015
3	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 08/2012
3	Messenger RNA (mRNA)IBA 12/2017 - 10/2016
3	GlycolipidsIBA 08/2014 - 09/2004
3	Ethambutol (Myambutol)FDA LinkGeneric 01/2014 - 03/2003
3	AntigensIBA 08/2011 - 06/2008
3	AerosolsIBA 02/2007 - 08/2003
2	Coenzyme A (CoA)IBA 11/2021 - 12/2016
2	Drug CombinationsIBA 01/2021 - 09/2013
2	ElementsIBA 11/2018 - 05/2009
2	Antimicrobial PeptidesIBA 01/2016 - 01/2009
2	EicosanoidsIBA 01/2016 - 07/2014
2	mycobactinsIBA 08/2014 - 01/2012
2	NAD (NADH)IBA 11/2013 - 07/2008
2	Metronidazole (Metric)FDA LinkGeneric 08/2013 - 08/2012
2	Meropenem (Merrem)FDA LinkGeneric 10/2012 - 02/2009
2	OPC-67683IBA 01/2012 - 04/2008
2	Mycolic Acids (Mycolic Acid)IBA 01/2012 - 12/2003
2	Biotin (Vitamin H)FDA Link 11/2011 - 09/2011
2	Peptides (Polypeptides)IBA 02/2010 - 07/2002
2	Sulfoglycosphingolipids (Sulfatides)IBA 06/2005 - 05/2004
1	Cephalosporins (Cephalosporin Antibiotics)IBA 11/2022
1	LactamsIBA 11/2022
1	MacrolidesIBA 01/2022
1	5- (2- oxopropylideneamino)- 6- d- ribitylaminouracilIBA 01/2021
1	Proline (L-Proline)FDA Link 01/2020
1	Glutamic Acid (Glutamate)FDA Link 01/2020
1	Glycerol (Glycerine)FDA LinkGeneric 01/2020
1	propionamideIBA 01/2020
1	Inflammation MediatorsIBA 11/2019
1	CytochromesIBA 10/2019
1	Oxidoreductases (Dehydrogenase)IBA 10/2019
1	AmidesIBA 10/2019
1	bedaquiline (R207910)IBA 01/2019
1	Adenosine Triphosphate (ATP)IBA 01/2019
1	MagnesiumIBA 11/2018
1	Nucleic AcidsIBA 11/2018
1	Antigen-Antibody Complex (Immune Complex)IBA 01/2018
1	Complement System Proteins (Complement)IBA 01/2018
1	Triglycerides (Triacylglycerol)IBA 01/2018
1	CholesterolIBA 01/2018
1	Ofloxacin (Ofloxacine)FDA LinkGeneric 01/2017
1	GuanineIBA 01/2017
1	PantetheineIBA 12/2016
1	Heme (Haem)IBA 10/2016
1	Heme Oxygenase-1IBA 10/2016
1	AntioxidantsIBA 10/2016

Therapy/Procedure

23	Therapeutics 01/2021 - 01/2004
11	Drug Therapy (Chemotherapy) 02/2015 - 03/2003
5	Duration of Therapy 01/2022 - 10/2004
3	Injections 01/2021 - 10/2012
2	Lasers (Laser) 01/2016 - 10/2015
2	Aftercare (After-Treatment) 01/2016 - 12/2014
1	Immunotherapy 01/2021